Enhancer-Associated LncRNA-ITGA2 Promotes Vascular Remodeling Through ITGA2
This study identifies a novel mechanism by which elncRNA (LncRNA-ITGA2), in a NONO-dependent manner, mediates interactions between enhancer-ITGA2 and promoter-ITGA2, resulting in increased ITGA2 expression and subsequently promoting VSMC proliferation and migration. These findings highlight LncRNA-ITGA2 as an attractive diagnostic and therapeutic target for human proliferative vascular diseases.
Authors
- Wendong Tang
- Zhifu Guo (ORCID: https://orcid.org/0000-0003-2730-818X)
- Faguang Jin (ORCID: https://orcid.org/0000-0002-2466-3306)
- Bili Zhang
- Junfeng Jiang (ORCID: https://orcid.org/0000-0003-2696-2032)
- Xian Guo
- Xianxian Zhao (ORCID: https://orcid.org/0000-0002-0648-3897)
- Qiang Xu (ORCID: https://orcid.org/0000-0003-0850-1419)
- Pan Hou
- Yue Wang (ORCID: https://orcid.org/0000-0002-0564-3019)
- Pan Li (ORCID: https://orcid.org/0009-0004-8763-5830)
- Si’ang Zhang
- Mingyao Zhou (ORCID: https://orcid.org/0000-0003-4804-8057)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Second Military Medical University (CN)
- Chinese General Hospital College of Nursing and Liberal Arts (PH)
- Changhai Hospital (CN)
- PLA Navy General Hospital (CN)
- Central Hospital of Wuhan (CN)
- Wuhan General Hospital of Guangzhou (CN)
- Tang Du Hospital (CN)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1161/circresaha.124.325443
- Citations
- 10
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 9.36