Synthesis of Dimethyl (Z)-((3-oxoindolin-2-ylidene) (aryl)methyl)phosphonates Through Tandem Cadogan and Arbuzov Reactions
A novel method employing a tandem Cadogan and Arbuzov reaction sequence has been developed, providing access to a series of previously unreported dimethyl (Z)-((3-oxoindolin-2-ylidene)(aryl)methyl)phosphonates. Restricted rotation of the aryl substituent, particularly in the presence of ortho substituents, gives axial chirality to these compounds.
Authors
- Daniil D. Ganusenko (ORCID: https://orcid.org/0000-0002-1734-9693)
- Дмитрий А. Аксенов (ORCID: https://orcid.org/0000-0002-0727-9652)
- Nicolai A. Aksenov (ORCID: https://orcid.org/0000-0002-7125-9066)
- А. В. Аксенов (ORCID: https://orcid.org/0000-0002-6644-9949)
- Alexander E. Kurlikov
- Alexander P. Barbolin
- Polina S. Karaseva (ORCID: https://orcid.org/0009-0005-3794-4958)
Institutions
- North-Caucasus Federal University (RU)
Publication Details
- Journal
- Molbank
- Published
- 2025-05-05
- DOI
- https://doi.org/10.3390/m2002
- Primary Topic
- Synthesis and Reactivity of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Russian Science Foundation