Investigating the Impact of Maternal Obesity on Disease Severity in a Mouse Model of Preeclampsia
These findings challenge the prevailing assumption that obesity drives hypertension, endothelial dysfunction, and inflammatory markers. The differential vascular and physiological responses observed in the obese dams highlight the complexity of obesity-preeclampsia interactions and underscore the need for refined preclinical models to disentangle mechanistic contributions. This work has implications for personalised management strategies and targeted therapeutic interventions in obese pregnancies at risk of preeclampsia.
Authors
- Sally Beard
- Fiona Brownfoot (ORCID: https://orcid.org/0000-0002-1439-7016)
- Natalie Binder (ORCID: https://orcid.org/0000-0002-8943-2269)
- Bianca R. Fato (ORCID: https://orcid.org/0000-0003-1908-784X)
- Natalie J. Hannan (ORCID: https://orcid.org/0000-0001-8446-2250)
- Elif Kadife
- Natasha de Alwis (ORCID: https://orcid.org/0000-0001-8376-0096)
- Yeukai T. M. Mangwiro
Institutions
- The University of Melbourne (AU)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Mercy Hospital for Women (AU)
Publication Details
- Journal
- Nutrients
- Published
- 2025-05-05
- DOI
- https://doi.org/10.3390/nu17091586
- Citations
- 1
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 2.06
Funders
- Australian Research Council
- National Health and Medical Research Council