Physical Encapsulation and Chemotherapy: A Synergistic Hydrogel Strategy for Tumor Suppression

Conventional chemotherapy remains a fundamental strategy for cancer treatment but is often limited by systemic toxicity. To address this challenge, Mix Gel is developed as a hybrid hydrogel combining the biocompatibility of decellularized omentum hydrogel and the mechanical stability of sodium alginate. Peritumoral injection of Mix Gel effectively achieves tumor encapsulation and growth inhibition. To enhance therapeutic efficacy, doxorubicin is incorporated, forming DOX-Mix Gel, which synergistically improves antitumor outcomes through physical encapsulation and sustained drug release. In vivo, DOX-Mix Gel significantly inhibits tumor proliferation, induces apoptosis, disrupts blood supply, and triggers metabolic stress, resulting in marked tumor suppression. Mix Gel provides a scalable, minimally invasive, and clinically promising strategy for solid tumor therapy.

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Publication Details

Journal
Advanced Healthcare Materials
Published
2025-05-05
DOI
https://doi.org/10.1002/adhm.202500511
Citations
4
Primary Topic
Graphene and Nanomaterials Applications
Type
article
Field-Weighted Citation Impact
2.70

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article

Physical Encapsulation and Chemotherapy: A Synergistic Hydrogel Strategy for Tumor Suppression

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4 citations
Advanced Healthcare Materials
Graphene and Nanomaterials Applications
2.70
article

Physical Encapsulation and Chemotherapy: A Synergistic Hydrogel Strategy for Tumor Suppression

Mengru Jin, Yijun Chu, Youxue Zhang, Da Pang, Lingling Tao, Weiguang Yuan, Siyu Liu, Xi Chen, Hui Li, Yuanyuan Yu, Siwei Li, Xianyu Zhang, Yajie Gong
article en
4 citations

Abstract

Conventional chemotherapy remains a fundamental strategy for cancer treatment but is often limited by systemic toxicity. To address this challenge, Mix Gel is developed as a hybrid hydrogel combining the biocompatibility of decellularized omentum hydrogel and the mechanical stability of sodium alginate. Peritumoral injection of Mix Gel effectively achieves tumor encapsulation and growth inhibition. To enhance therapeutic efficacy, doxorubicin is incorporated, forming DOX-Mix Gel, which synergistically improves antitumor outcomes through physical encapsulation and sustained drug release. In vivo, DOX-Mix Gel significantly inhibits tumor proliferation, induces apoptosis, disrupts blood supply, and triggers metabolic stress, resulting in marked tumor suppression. Mix Gel provides a scalable, minimally invasive, and clinically promising strategy for solid tumor therapy.

Advanced Healthcare MaterialsVol. 14(20)
Harbin Medical University (CN), Heilongjiang Academy of Sciences (CN), Third Affiliated Hospital of Harbin Medical University (CN), Second Affiliated Hospital of Harbin Medical University (CN)
National Natural Science Foundation of China
Good health and well-being
Openalex Percentile: Top 11%
Graphene and Nanomaterials Applications
2.70
DOISourceOpenAlex
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