The Causal Association Analysis between Depression and Cerebrospinal Fluid: From the Perspective of Mendelian Randomization
This study provides novel insights into the potential causal relationship between CSF metabolites and depression, highlighting 14 key metabolites with significant associations. The robustness of these findings is supported by MR and sensitivity analyses. Further longitudinal studies are warranted to confirm the clinical relevance of these CSF biomarkers in MDD.
Authors
- Yu Zhang (ORCID: https://orcid.org/0009-0001-4396-0525)
- Zhuo Liu (ORCID: https://orcid.org/0000-0002-1137-7220)
- Ping Wu (ORCID: https://orcid.org/0000-0002-0788-6268)
Institutions
- Central South University (CN)
- Hunan University of Traditional Chinese Medicine (CN)
- Changsha Medical University (CN)
- Hunan Academy of Traditional Chinese Medicine (CN)
- The First People's Hospital of Changde (CN)
Publication Details
- Journal
- Psychology Research and Behavior Management
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/prbm.s508610
- Citations
- 2
- Primary Topic
- Medical Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.76
Funders
- Natural Science Foundation of Hunan Province