Impaired Mitochondrial Biogenesis Inhibits Epithelial-Mesenchymal Transition in Villi of PCOS Patients
The villi of PCOS patients with euploid miscarriage exhibited impaired mitochondrial biogenesis. Androgen-induced downregulation of TFAM impeded EMT via ROS/YAP axis in trophoblast cell.
Authors
- Qingyun Mai (ORCID: https://orcid.org/0000-0003-2571-7051)
- Yan Kang Xu (ORCID: https://orcid.org/0000-0002-8632-4270)
- Huiying Jie (ORCID: https://orcid.org/0000-0003-1091-3789)
- Lu Luo (ORCID: https://orcid.org/0000-0002-9151-6410)
- Canquan Zhou (ORCID: https://orcid.org/0000-0001-6798-9552)
- Simin Liu (ORCID: https://orcid.org/0000-0003-2098-3844)
- Minghui Chen (ORCID: https://orcid.org/0000-0001-5742-0450)
- J. Tan (ORCID: https://orcid.org/0009-0004-5086-9959)
- Bing Cai (ORCID: https://orcid.org/0000-0002-3632-9866)
- Yangxing Wen
- Yuan Yuan (ORCID: https://orcid.org/0009-0002-9540-2100)
Institutions
- Sun Yat-sen University (CN)
- Key Laboratory of Guangdong Province (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Children's Hospital (TN)
Publication Details
- Journal
- Endocrinology
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1210/endocr/bqaf076
- Citations
- 1
- Primary Topic
- Hair Growth and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.84
Funders
- Natural Science Foundation of Guangdong Province
- Guangzhou Municipal Science and Technology Project
- Special Project for Research and Development in Key areas of Guangdong Province
- Basic and Applied Basic Research Foundation of Guangdong Province