Automated and Decentralized Genomic Profiling of Plasma Cell-Free DNA for Identification of Targetable and Resistance Alterations in Advanced Solid Tumors
This study underscores the clinical feasibility of an automated, decentralized cfDNA genomic profiling approach. It emphasizes the importance of considering confounding clinical factors when selecting plasma- or tissue-based profiling assay. Such an approach holds promise for enhancing patient access to timely genomic profiling and targeted therapy selection.
Authors
- Yoon Ming Chin (ORCID: https://orcid.org/0000-0003-4667-3561)
- Shunji Takahashi (ORCID: https://orcid.org/0000-0002-5031-1953)
- Siew‐Kee Low (ORCID: https://orcid.org/0000-0003-2386-0698)
- Naoki Fukuda (ORCID: https://orcid.org/0000-0002-5475-9309)
- Akiyoshi Kasuga (ORCID: https://orcid.org/0000-0002-2234-1135)
- Takeru Wakatsuki (ORCID: https://orcid.org/0000-0002-1463-3859)
- Naomi Hayashi
- Masumi Otaki
- Ippei Fukada (ORCID: https://orcid.org/0000-0001-7272-3708)
- Mayu Yunokawa (ORCID: https://orcid.org/0000-0001-7354-6977)
- Mari Hosonaga (ORCID: https://orcid.org/0000-0001-8525-2941)
- Kensei Yamaguchi (ORCID: https://orcid.org/0000-0001-6887-5709)
- Xiaofei Wang (ORCID: https://orcid.org/0000-0002-8540-309X)
- Ting Chan (ORCID: https://orcid.org/0000-0002-8707-4592)
- Eiji Shinozaki (ORCID: https://orcid.org/0000-0003-1831-0536)
- Yusuke Nakamura
Institutions
- The University of Melbourne (AU)
- Cancer Institute (WIA) (IN)
- National Institute of Biomedical Innovation, Health and Nutrition (JP)
- Japanese Foundation For Cancer Research (JP)
Publication Details
- Journal
- Clinical Chemistry
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1093/clinchem/hvaf045
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00