Postoperative Unstimulated Thyroglobulin Accurately Predicts Outcomes in High‐Risk Differentiated Thyroid Cancer: A Retrospective Cohort Study
Postoperative UTg is a strong prognostic marker in high-risk DTC patients, providing a non-inferior alternative to STg with greater accessibility and fewer side effects. We propose a clinical algorithm to optimize the management of these cases. When UTg levels exceed 2.1 ng/mL, particularly higher than 3.8 ng/mL, investigation of potentially resectable metastatic foci should be considered before radioiodine therapy. Prospective studies are needed to validate this algorithm.
Authors
- Rafael De Cicco (ORCID: https://orcid.org/0000-0003-2505-0461)
- Carolina Ferraz da Silva
- Rosália do Prado Padovani (ORCID: https://orcid.org/0000-0002-5497-6813)
- Adriano Namo Cury
- Marcelo Soares Schalch (ORCID: https://orcid.org/0000-0002-8318-4663)
- Júlia Isabel Richter Cicogna (ORCID: https://orcid.org/0000-0003-1489-110X)
- S. Noguchi (ORCID: https://orcid.org/0000-0001-7243-9002)
- Layanne Nascimento Fraga (ORCID: https://orcid.org/0000-0003-4801-3049)
- Giovanna Marcela Vieira Della Negra
Institutions
- Irmandade da Santa Casa de Misericórdia de São Paulo (BR)
- Instituto do Câncer do Estado de São Paulo (BR)
- Faculdade de Ciências Médicas da Santa Casa de São Paulo (BR)
Publication Details
- Journal
- Clinical Endocrinology
- Published
- 2025-05-04
- DOI
- https://doi.org/10.1111/cen.15260
- Citations
- 1
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.29