Reevaluating BED in cervical cancer HDR brachytherapy: source decay and tissue-specific repair significantly impact radiobiological dose

These findings confirm that source decay significantly impacts BED in cervical cancer treatment, affecting both tumor tissues with varying radiosensitivities and normal tissues. The simplified BED formula tends to overestimate the actual dose, especially at a source activity of 2 Ci, highlighting the necessity of using the full <i>BEDg</i> model for accurate dosimetric evaluation in HDR brachytherapy.