Circulating CD8 T cells from patients with mild-to-moderate psoriasis are functionally impaired
Patients with mild-to-moderate psoriasis showed a significant decrease in CD8 T memory cells and reduced release of cytotoxic mediators by CD8 T cells. Thus, this indicates that psoriasis impacts the functionality of circulating CD8 T cells.
Authors
- Paola Di Meglio (ORCID: https://orcid.org/0000-0002-2066-7780)
- Rajia Bahri (ORCID: https://orcid.org/0000-0001-5969-5941)
- Juliet N. Barker (ORCID: https://orcid.org/0000-0002-9030-183X)
- Yiqiao Chen (ORCID: https://orcid.org/0000-0003-3264-441X)
- Christopher E.M. Griffiths (ORCID: https://orcid.org/0000-0001-5371-4427)
- Chiara Tontini (ORCID: https://orcid.org/0000-0002-8437-8697)
- Isabella Tosi (ORCID: https://orcid.org/0000-0002-2638-8539)
- Silvia Bulfone‐Paus (ORCID: https://orcid.org/0000-0002-5764-8516)
Institutions
- King's College London (GB)
- Manchester Academic Health Science Centre (GB)
- University of Manchester (GB)
- King's College Hospital (GB)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1585378
- Citations
- 1
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Psoriasis Association
- King's College London
- Medical Research Council