Understanding adaptation to fluconazole: comparative insights into tolerance and resistance in Saccharomyces cerevisiae and Candida albicans
Transcriptome analysis indicated that petites up-regulated efflux mechanisms while down-regulating most <i>ERG</i> genes. This suggests that, unlike petite-negative <i>C. albicans</i>, petite-positive <i>S. cerevisiae</i> swiftly transitions to a petite phenotype upon exposure to fluconazole, resulting in enhanced resistance but diminished tolerance. This evolutionary divergence emphasizes the need for additional studies on fluconazole tolerance in other pathogenic fungi.
Authors
- Yonghui Jia
- Liangsheng Guo (ORCID: https://orcid.org/0000-0002-1596-0851)
- Yi Xu (ORCID: https://orcid.org/0000-0001-8971-9334)
- Yubo Dong (ORCID: https://orcid.org/0009-0003-3272-1363)
- Jing Wang (ORCID: https://orcid.org/0000-0001-9496-6276)
- Weifang Wang (ORCID: https://orcid.org/0000-0002-1690-6611)
- Lijun Zheng (ORCID: https://orcid.org/0000-0002-3283-3619)
Institutions
- Soochow University (CN)
- 82th Hospital of Pla (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Jinzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-05-05
- DOI
- https://doi.org/10.3389/fcimb.2025.1519323
- Citations
- 3
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 4.19
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province