Self and parasite-derived peptides selected upon DERAA-bearing HLA-DRB1 alleles activate CD4+ T cells from Chagas cardiomyopathy patients and are associated with ventricular dysfunction
Our findings highlight the ability of CD4+ T-cells from CCC patients to recognize and react to foreign and self-peptides, thereby emphasizing the importance of HLA-DRB1 alleles in the presentation of potentially pathogenic antigens and in the amplification of CCC pathology.
Authors
- Walderez O. Dutra (ORCID: https://orcid.org/0000-0002-7586-9996)
- Kenneth J. Gollob (ORCID: https://orcid.org/0000-0003-4184-3867)
- Andréa Teixeira‐Carvalho (ORCID: https://orcid.org/0000-0003-2814-5183)
- Thaiany Goulart de Souza e Silva (ORCID: https://orcid.org/0000-0002-1068-0156)
- Jorge Kalil (ORCID: https://orcid.org/0000-0001-8415-4274)
- María A. Juliano (ORCID: https://orcid.org/0000-0003-2994-0947)
- Amanda Braga Figueiredo (ORCID: https://orcid.org/0000-0002-4759-6679)
- Alexandre Negrão Pantaleão (ORCID: https://orcid.org/0000-0002-9008-5751)
- Juliana de Souza Apostólico (ORCID: https://orcid.org/0000-0002-3507-3117)
- Maria Carmo Pereira Nunes (ORCID: https://orcid.org/0000-0001-8801-1828)
- Kátia L.P. Morais (ORCID: https://orcid.org/0000-0001-8877-5887)
- Eula G. A. Neves
- Luiz Juliano (ORCID: https://orcid.org/0000-0002-5589-2822)
- H. Rodrigues (ORCID: https://orcid.org/0000-0003-3463-6720)
- Antônio Mutarelli
- Silvana Silva Araújo
Institutions
- Universidade Federal de Minas Gerais (BR)
- Hospital Israelita Albert Einstein (BR)
- Faculdade de Ciências Médicas de Minas Gerais (BR)
- Instituto da Visão (BR)
- Hospital do Coração (BR)
- Instituto do Coração (PT)
- Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais (BR)
- Fundação Oswaldo Cruz (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1527115
- Citations
- 1
- Primary Topic
- Trypanosoma species research and implications
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases