Physical and drug- releasing properties of a cement containing simvastatin (SimCeram)
SimCeram showed higher compressive strength and calcium release compared to MTA. Given simvastatin's beneficial properties-such as anti-inflammatory effects, angiogenesis promotion, and the ability to induce differentiation of dental pulp stem cells-along with the significant calcium ion release from the calcium silicate-based component of the cement, SimCeram could be a promising material for vital pulp therapy.
Authors
- Mohammad Hossein Boskabady (ORCID: https://orcid.org/0000-0001-5736-9755)
- Mitra Moodi (ORCID: https://orcid.org/0000-0002-8877-6609)
- Roshanak Salari (ORCID: https://orcid.org/0000-0003-4690-7823)
- Hossein Bagheri (ORCID: https://orcid.org/0000-0003-1269-7434)
- Melika Hoseinzadeh (ORCID: https://orcid.org/0000-0002-8463-956X)
- Iman Parisay (ORCID: https://orcid.org/0000-0001-7391-9542)
Institutions
- Mashhad University of Medical Sciences (IR)
- Gorgan University of Agricultural Sciences and Natural Resources (IR)
Publication Details
- Journal
- BMC Oral Health
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1186/s12903-025-06045-8
- Citations
- 3
- Primary Topic
- Endodontics and Root Canal Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.37
Funders
- Mashhad University of Medical Sciences