Chromosome-scale scaffolds of the fungus gnat genome reveal multi-Mb-scale chromosome-folding interactions, centromeric enrichments of retrotransposons, and candidate telomere sequences
The chromosome scaffolds were shown to be of exceptional quality, including loci harboring horizontally-transferred genes. Repeat analyses demonstrate family-specific biases and telomere repeat candidates. Hi-C analyses revealed the sequences of ultra-long-range interactions on the X chromosome. The chromosome-scale scaffolds pave the way for further studies of the unusual chromosome movements in Bradysia coprophila.
Authors
- Allan C. Spradling (ORCID: https://orcid.org/0000-0002-5251-1801)
- John Urban (ORCID: https://orcid.org/0000-0001-9270-6569)
- Susan A. Gerbi (ORCID: https://orcid.org/0000-0003-2148-7180)
Institutions
- Howard Hughes Medical Institute (US)
- Carnegie Institution for Science (US)
- Brown University (US)
- Department of Embryology (US)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1186/s12864-025-11573-2
- Citations
- 2
- Primary Topic
- Chromosomal and Genetic Variations
- Type
- article
- Field-Weighted Citation Impact
- 3.50
Funders
- Howard Hughes Medical Institute
- National Institutes of Health