TRIM28 mediates Mettl5 ubiquitination to promotes Th2 polarization
Low Mettl5 levels in airway CD4<sup>+</sup> T cells resulted in Th2 polarization. Inhibition of TRIM28 restored the levels of Mettl5 in airway CD4<sup>+</sup> T cells, and suppressed experimental AA.
Authors
- Ping Tang (ORCID: https://orcid.org/0000-0003-0253-1836)
- Sicheng Miao (ORCID: https://orcid.org/0009-0006-2045-0852)
- Yun Liao
- Yu Liu (ORCID: https://orcid.org/0000-0002-7968-0162)
- Yuanyi Zhang (ORCID: https://orcid.org/0000-0002-2609-5672)
- Beiping Miao (ORCID: https://orcid.org/0000-0003-2307-3280)
- Xiwen Zhang (ORCID: https://orcid.org/0000-0002-5245-0703)
- Ping-Chang Yang
- Lihua Mo
- Bailing Xie
- Yifeng Dong (ORCID: https://orcid.org/0009-0009-9910-2819)
- Haoyue Zheng
Institutions
- Shenzhen University (CN)
- Shenzhen Luohu People's Hospital (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1524633
- Citations
- 1
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80