QTC INTERVAL PROLONGATION: ROLE OF POLYPHARMACY, DRUG INTERACTION AND CONSIDERATIONS FOR CLINICAL PRACTICE
Highlights Acquired long QT syndrome is a rare disease, but the frequency of QTc prolongation increases with polypragmasia. Abstract Acquired long QT syndrome is a rare condition. However, the prevalence of prolonged QTc interval increases among patients with polypharmacy. The risk of both QTc interval prolongation and torsades de pointes (TdP) tachycardia escalates exponentially with the concomitant use of multiple QTc-prolonging drugs. This article explores the underlying mechanisms of the condition and methods to mitigate the risk of potentially fatal arrhythmias.
Authors
- Rais K. Khayretdinov (ORCID: https://orcid.org/0000-0002-7983-642X)
- V. P. Kuzmin (ORCID: https://orcid.org/0000-0002-7019-650X)
- Victoria Rodionova (ORCID: https://orcid.org/0009-0008-7271-8077)
- О. А. Рубаненко (ORCID: https://orcid.org/0000-0001-9351-6177)
- С. П. Кривова (ORCID: https://orcid.org/0000-0002-1100-3798)
- И. Л. Давыдкин (ORCID: https://orcid.org/0000-0002-4318-4247)
- Irina A. Zolotovskaya
Institutions
- Ministry of Health of the Russian Federation (RU)
- Samara State Medical University (RU)
- Samara Regional Clinical Oncology Center (RU)
Publication Details
- Journal
- Complex Issues of Cardiovascular Diseases
- Published
- 2025-05-05
- DOI
- https://doi.org/10.17802/2306-1278-2025-14-2-127-135
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00