Multiomic profiling of glioblastoma metabolic lesions reveals complex intratumoral genomic evolution and dipeptidase-1-driven vascular proliferation
Hypermetabolic lesions are associated with a higher frequency of genomic abnormalities and dipeptidase 1 emerges as a novel diagnostic and prognostic vascular marker for hypermetabolic lesions. This study underscores a spatial genomic evolution with diagnostic implications and elucidates challenges and opportunities crucial for the development of novel therapeutic strategies.
Authors
- Clara Oudenaarden (ORCID: https://orcid.org/0000-0002-5466-0755)
- Peter Grupe
- Bjarne Winther Kristensen (ORCID: https://orcid.org/0000-0002-6352-0826)
- Lars van Brakel Andersen
- Mark Burton (ORCID: https://orcid.org/0000-0002-3782-5933)
- Frantz Rom Poulsen (ORCID: https://orcid.org/0000-0001-5715-6901)
- Jeanette Krogh Petersen (ORCID: https://orcid.org/0000-0002-5093-5985)
- Atul Anand (ORCID: https://orcid.org/0000-0001-7474-5433)
- Philip Ahle Erichsen
- Torben A. Kruse (ORCID: https://orcid.org/0000-0002-2460-6483)
- Christian Bonde Pedersen (ORCID: https://orcid.org/0000-0003-3761-0446)
- Martin J. Larsen (ORCID: https://orcid.org/0000-0003-4107-8771)
- Mads Thomassen (ORCID: https://orcid.org/0000-0003-0078-1217)
Institutions
- University of Copenhagen (DK)
- University of Southern Denmark (DK)
- Odense University Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1093/neuonc/noaf071
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gentofte Hospital
- Novo Nordisk
- Odense Universitetshospital
- Rigshospitalet
- Syddansk Universitet
- Novo Nordisk Fonden
- Klinisk Institut, Syddansk Universitet