Predictive Biomarkers of Acute Kidney Injury in COVID-19: Distinct Inflammatory Pathways in Patients with and Without Pre-Existing Chronic Kidney Disease
The differential roles of IL-6, NLR, and WBC in predicting AKI onset highlight distinct physiopathological pathways influenced by COVID-19. In CKD+ patients, chronic inflammation and immune dysregulation are key drivers of AKI, with IL-6 and NLR serving as robust markers of this inflammatory state. In contrast, in CKD- patients, AKI may be more influenced by acute inflammatory responses and infectious factors, as reflected by WBC count.
Authors
- Nicola Scichilone (ORCID: https://orcid.org/0000-0001-6400-6573)
- Giuseppe Mulè (ORCID: https://orcid.org/0000-0002-8500-8671)
- Giulio Geraci (ORCID: https://orcid.org/0000-0003-3806-1151)
- Katia Montalbano
- Alida Benfante (ORCID: https://orcid.org/0000-0002-8609-0814)
- Leonardo Calandra (ORCID: https://orcid.org/0000-0003-0127-4751)
- Alessandra Sorce (ORCID: https://orcid.org/0000-0002-5267-3616)
- Caterina Carollo (ORCID: https://orcid.org/0000-0002-6767-8823)
- Emanuele Cirafici (ORCID: https://orcid.org/0009-0002-4934-0818)
Institutions
- Università degli Studi di Enna Kore (IT)
- Ospedale Vincenzo Cervello (IT)
- University of Palermo (IT)
Publication Details
- Journal
- Life
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3390/life15050720
- Citations
- 2
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.79