Design, synthesis and evaluation of antibacterial activity and mechanism of novel 1‐<scp><i>H</i></scp>‐indole‐3‐pyrazolamide derivatives
This study presents a promising 1-H-indole-3-pyrazole-mercaptoacetamide compound as a novel antibacterial approach. Compound 7 manifests inhibitory actions on Xoo growth by disrupting bacterial flagella assembly, biotin synthesis, the two-component system and the type VI secretion system, showcasing substantial potential for novel antibacterial agent development. © 2025 Society of Chemical Industry.
Authors
- Zhurui Li (ORCID: https://orcid.org/0009-0003-6683-8842)
- Cheng‐Peng Li (ORCID: https://orcid.org/0000-0002-6798-9541)
- Yue Zhou (ORCID: https://orcid.org/0009-0005-3498-5025)
- Zhenchao Wang (ORCID: https://orcid.org/0000-0003-1859-0128)
- Danping Chen (ORCID: https://orcid.org/0009-0001-9851-037X)
- Chenchen Li (ORCID: https://orcid.org/0000-0002-2956-7639)
- Mengting Liu (ORCID: https://orcid.org/0000-0003-4972-9006)
- Yan Li (ORCID: https://orcid.org/0000-0002-2781-2119)
- Guiping Ouyang (ORCID: https://orcid.org/0000-0002-7207-8582)
Institutions
- Guizhou University (CN)
Publication Details
- Journal
- Pest Management Science
- Published
- 2025-05-04
- DOI
- https://doi.org/10.1002/ps.8864
- Citations
- 6
- Primary Topic
- Plant-Microbe Interactions and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 10.50
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guizhou Province
- National Key Research and Development Program of China