Transfer learning identifies bacterial signatures for cross‐regional diagnosis of type 2 diabetes and enable stage‐sensitive dietary fiber intervention
DeepMicroFinder is a deep learning framework designed to update the existing disease diagnosis model to generate a transfer model by leveraging region-specific microbiome datasets and transfer learning approach. This framework effectively overcomes the limitation of regional effects in the gut microbiome, enabling accurate cross-regional disease detection. Microbial markers related to type 2 diabetes (T2D) were identified by DeepMicroFinder, and subsequently validated in independent T2D cohorts undergoing dietary fiber interventions.
Authors
- Yuan-Tao Liu (ORCID: https://orcid.org/0000-0002-5071-9780)
- Mingyue Cheng (ORCID: https://orcid.org/0000-0003-1243-5039)
- Xiaoli Ma (ORCID: https://orcid.org/0000-0001-7930-4944)
- Chenhong Zhou (ORCID: https://orcid.org/0000-0001-5345-1372)
- Qunye Zhang
- Kaile Yue
- Bin Chen (ORCID: https://orcid.org/0000-0002-0925-9209)
- Zhongchao Wang
- Changying Zhao (ORCID: https://orcid.org/0000-0003-0023-0378)
- Minxiu Yao
- Kang Ning (ORCID: https://orcid.org/0000-0003-3325-5387)
- Haohong Zhang (ORCID: https://orcid.org/0000-0001-6267-4244)
- Lei Zhang (ORCID: https://orcid.org/0000-0003-4284-2604)
- Chuandi Jin (ORCID: https://orcid.org/0009-0009-6351-0706)
- Dai-Feng Jiang
- Yihui Wang (ORCID: https://orcid.org/0000-0001-8477-6145)
- Nan Wang
- Haiyan Wang (ORCID: https://orcid.org/0009-0000-6582-9301)
- Jun Wang (ORCID: https://orcid.org/0000-0001-8708-3096)
- Zhe Wang (ORCID: https://orcid.org/0000-0003-4036-7969)
- Yangang Wang (ORCID: https://orcid.org/0000-0001-6597-420X)
- Fanghua Zhang (ORCID: https://orcid.org/0000-0002-9586-5837)
- Liang Gao
- Guoping Zhao
- Dongming Hu
- Zixin Kang (ORCID: https://orcid.org/0009-0005-4993-7827)
- Dashuang Sheng
Institutions
- Qingdao University (CN)
- Shandong University (CN)
- Shanghai Institute of Nutrition and Health (CN)
- Shandong Provincial Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
- Shandong Academy of Sciences (CN)
- Qilu Hospital of Shandong University (CN)
- Qingdao Eighth People's Hospital (CN)
- Shandong First Medical University (CN)
- University of Chinese Academy of Sciences (CN)
- State Key Laboratory of Microbial Technology
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- iMetaOmics.
- Published
- 2025-05-04
- DOI
- https://doi.org/10.1002/imo2.70021
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shandong University
- National Natural Science Foundation of China