<scp>PMN</scp>‐<scp>MDSCs</scp> Orchestrate the Immunosuppressive Microenvironment in the Lung and Are Associated With Clinical Outcome in Bronchiectasis
These findings suggest that PMN-MDSCs accumulate and establish an immunosuppressive microenvironment in the lung via ARG-1 in bronchiectasis, which is associated with clinical outcome and response to antibiotic treatment, highlighting a potential role of PMN-MDSCs in bronchiectasis progression.
Authors
- Wenqing Yang (ORCID: https://orcid.org/0000-0002-4721-6197)
- Xiaoping Ning (ORCID: https://orcid.org/0000-0002-5940-0338)
- Xu Shi (ORCID: https://orcid.org/0009-0001-4916-9769)
- Jielin Duan (ORCID: https://orcid.org/0000-0003-4985-1191)
- Linling Cheng (ORCID: https://orcid.org/0000-0001-5254-7735)
- Meihua Dong
- Guan Yang (ORCID: https://orcid.org/0000-0002-4026-6976)
- Zhaowei Yang (ORCID: https://orcid.org/0000-0002-1805-4360)
- Zexuan Lian (ORCID: https://orcid.org/0000-0003-4134-6000)
- Ying Jiang (ORCID: https://orcid.org/0000-0002-1309-9922)
- Peiying Huang (ORCID: https://orcid.org/0000-0002-6814-0611)
- Bizhou Li (ORCID: https://orcid.org/0000-0001-6046-3013)
- Ruchong Chen (ORCID: https://orcid.org/0000-0001-5376-8230)
- Naijian Li (ORCID: https://orcid.org/0000-0002-8492-9524)
- Yubiao Guo (ORCID: https://orcid.org/0000-0003-3153-8121)
- Li He (ORCID: https://orcid.org/0000-0001-9313-1218)
- Ruidong Mo (ORCID: https://orcid.org/0009-0009-0148-301X)
- Wanjun Wang (ORCID: https://orcid.org/0000-0003-1770-2693)
- Zhifeng Huang (ORCID: https://orcid.org/0000-0001-8269-6731)
- Jing Li (ORCID: https://orcid.org/0000-0002-6459-7470)
- Nan Jia (ORCID: https://orcid.org/0000-0002-7164-6947)
- Haixiong Tang
- Mo Xian (ORCID: https://orcid.org/0000-0001-6300-0786)
Institutions
- City University of Hong Kong (HK)
- Henan University (CN)
- Guangdong Medical College (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Dongguan People’s Hospital (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Respirology
- Published
- 2025-05-04
- DOI
- https://doi.org/10.1111/resp.70045
- Citations
- 3
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation