Malignant Pheochromocytoma Presenting as Acute Coronary Syndrome: A Report of a Rare Case

Pheochromocytomas are rare tumors of the adrenal medulla. The classic presentation for this condition consists of a triad of symptoms: headache, tachycardia, and sweating in an episodic fashion. Rarely, pheochromocytomas are associated with cardiac pathology specifically acute coronary syndrome (ACS) and cardiomyopathy, which is usually attributed to catecholamine excess. They might also present secondary to elevations in blood pressure or arrhythmias. ECG changes are most often encountered as sinus tachycardia. We present a case of previously undiagnosed pheochromocytoma that showed up as ACS across multiple admissions in the setting of significant obstructive coronary artery disease. We aim to contribute to the growing literature reporting this uncommon presentation in order to showcase these cases to the medical audience.

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Journal
Cureus
Published
2025-05-04
DOI
https://doi.org/10.7759/cureus.83473
Primary Topic
Adrenal and Paraganglionic Tumors
Type
article
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0.00
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article

Malignant Pheochromocytoma Presenting as Acute Coronary Syndrome: A Report of a Rare Case

Rashid Nadeem, Samer Srouji, S. Sidhu, Natalia Reyes et al.
Cureus
Adrenal and Paraganglionic Tumors
article

Malignant Pheochromocytoma Presenting as Acute Coronary Syndrome: A Report of a Rare Case

Rashid Nadeem, Samer Srouji, S. Sidhu, Natalia Reyes, Mehdi Hakimipour
article en

Abstract

Pheochromocytomas are rare tumors of the adrenal medulla. The classic presentation for this condition consists of a triad of symptoms: headache, tachycardia, and sweating in an episodic fashion. Rarely, pheochromocytomas are associated with cardiac pathology specifically acute coronary syndrome (ACS) and cardiomyopathy, which is usually attributed to catecholamine excess. They might also present secondary to elevations in blood pressure or arrhythmias. ECG changes are most often encountered as sinus tachycardia. We present a case of previously undiagnosed pheochromocytoma that showed up as ACS across multiple admissions in the setting of significant obstructive coronary artery disease. We aim to contribute to the growing literature reporting this uncommon presentation in order to showcase these cases to the medical audience.

CureusVol. 17(5)
Saint Agnes Medical Center (US)
Good health and well-being
Openalex Percentile: Top 83%
Adrenal and Paraganglionic Tumors
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Malignant Pheochromocytoma Presenting as Acute Coronary Syndrome: A Report of a Rare Case — Rashid Nadeem, Samer Srouji, et al. · Cureus (2025) | TGRS Research Map | TGRS