Optimized Sampling Strategies for Isoniazid in East Asian Pediatric Populations Using Population Pharmacokinetics-Informed Approaches
Traditional adult sampling strategies are inadequate for East Asian pediatric populations. A tailored strategy involving up to five samples can accurately estimate INH PopPK parameters and should be considered for clinical implementation to optimize treatment and reduce patient sampling burden.
Authors
- Qingfeng He (ORCID: https://orcid.org/0000-0001-5795-1550)
- Dongsheng Ouyang (ORCID: https://orcid.org/0000-0002-1743-8610)
- Gehang Ju (ORCID: https://orcid.org/0000-0002-0721-5296)
- Gufen Zhang
- Wenyu Yang (ORCID: https://orcid.org/0000-0002-9057-4520)
- Chao Li (ORCID: https://orcid.org/0000-0001-7892-5538)
- Xin Liu (ORCID: https://orcid.org/0009-0009-5595-3195)
- Chenchen Zhang (ORCID: https://orcid.org/0000-0003-0458-6232)
- Lulu Chen (ORCID: https://orcid.org/0000-0003-0167-4632)
- Pan S (ORCID: https://orcid.org/0009-0005-5473-0265)
- Xiao Zhu
- Yeheng Peng
- Nan Yang
- Nuo Xu (ORCID: https://orcid.org/0009-0006-6428-8068)
Institutions
- Central South University (CN)
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Hunan Province Chest Hospital (CN)
- Sansure Biotech (China) (CN)
- Xiangya Hospital Central South University (CN)
- Changsha University of Science and Technology (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/dddt.s503987
- Citations
- 1
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.40