The effect of warm ischemic intervals on primary graft dysfunction in normothermic regional perfusion for donation after circulatory death heart transplant
In DCD normothermic regional perfusion heart transplant, >23 minutes of FWIT O<sub>2</sub> is associated with increased rates of severe PGD. However, increased FWIT O<sub>2</sub> was not associated with other outcomes, including mortality. Rejection of allografts on the basis of prolonged warm ischemia may lead to unnecessary discard of viable hearts.
Authors
- Hasan K. Siddiqi (ORCID: https://orcid.org/0000-0002-2274-9405)
- E. Quintana (ORCID: https://orcid.org/0009-0003-8799-123X)
- Timothy Harris
- Tarek Absi (ORCID: https://orcid.org/0000-0002-6777-6132)
- Aaron Williams (ORCID: https://orcid.org/0000-0001-6816-4368)
- Walter Navid (ORCID: https://orcid.org/0000-0002-8488-0812)
- Kelly H. Schlendorf (ORCID: https://orcid.org/0000-0002-8811-1957)
- Swaroop Bommareddi
- Arshad Ahmad (ORCID: https://orcid.org/0000-0002-0659-954X)
- Chen Chia Wang (ORCID: https://orcid.org/0009-0001-9491-7586)
- John M. Trahanas (ORCID: https://orcid.org/0000-0001-8644-5489)
- Mark Petrovic (ORCID: https://orcid.org/0000-0003-3922-3431)
- Douglas I. Walker (ORCID: https://orcid.org/0000-0003-2912-398X)
- Duc Nguyen (ORCID: https://orcid.org/0000-0001-7077-0236)
- C. Eidson (ORCID: https://orcid.org/0000-0002-9659-3984)
- Matthew D. Bacchetta (ORCID: https://orcid.org/0000-0003-4456-4484)
- Brian Lima (ORCID: https://orcid.org/0000-0002-2555-2229)
- Ashish S. Shah (ORCID: https://orcid.org/0000-0002-1821-9110)
- Stephen DeVries
Institutions
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Journal of Thoracic and Cardiovascular Surgery
- Published
- 2025-05-04
- DOI
- https://doi.org/10.1016/j.jtcvs.2025.03.037
- Citations
- 10
- Primary Topic
- Transplantation: Methods and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 20.06
Funders
- American Heart Association
- American Association for Thoracic Surgery
- National Institutes of Health
- National Institute of General Medical Sciences
- National Center for Advancing Translational Sciences