[225Ac]Ac-PSMA-617 production method: development of an efficient and reproducible radiolabelling process for establish a clinical routine production

the radiolabeling method employed in our experiments has demonstrated consistent reproducibility, enabling us to produce a radiopharmaceutical that meets pharmaceutical-grade standards. Greater difficulties occurred in defining the optimal procedures for quality controls, due to the unique physical properties of actinium. Efforts were made to standardize the quality control methods in accordance with pharmacopoeia standards; however, the methods' feasibility is still uncertain.