GMP compliant simplified fast and high yielding automated synthesis of [18F]fallypride without the need of HPLC purification
A GMP compliant automatic synthesis of [<sup>18</sup>F]fallypride including purification using simple solid phase extraction cartridges instead of HPLC was developed and evaluated. The implementation of the simplified synthesis in both used commercial modules allows efficient and reproducible Radiosynthesis of [<sup>18</sup>F]fallypride and leads to short synthesis times and high radiochemical yields with high radiochemical purity.
Authors
- Yi Zhao (ORCID: https://orcid.org/0000-0002-9908-0084)
- Ulf Lützen (ORCID: https://orcid.org/0000-0001-8483-5280)
- Maaz Zuhayra (ORCID: https://orcid.org/0000-0002-4064-5757)
- Michael Jüptner
- Ammar Alfteimi
- Alexander Helm (ORCID: https://orcid.org/0000-0003-4115-5618)
Institutions
- University Hospital Schleswig-Holstein (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2025-05-04
- DOI
- https://doi.org/10.1186/s41181-025-00343-w
- Citations
- 1
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36