Posttranscriptional RNA stabilization of telomeric RNAs FRG2, DBE-T, D4Z4 at human 4q35 in response to genotoxic stress and D4Z4 macrosatellite repeat length
Our study reveals unforeseen biochemical features of RNAs from clustered transcription units within the 4q35 subtelomere. Specifically, the FRG2, DBE-T and D4Z4-derived transcripts are chromatin-associated and are stabilized posttranscriptionally after induction by genotoxic stress. Remarkably, the extent of this response is modulated by the copy number of the D4Z4 repeats, raising new hypotheses about their regulation and function in human biology and disease.
Authors
- Paul D. Kaufman (ORCID: https://orcid.org/0000-0003-3089-313X)
- Valentina Salsi (ORCID: https://orcid.org/0000-0002-7133-0360)
- Monica Salani
- Rossella Ginevra Tupler (ORCID: https://orcid.org/0000-0002-3797-1789)
- Francesca Losi
Institutions
- University of Modena and Reggio Emilia (IT)
- University of Massachusetts Chan Medical School (US)
- Massachusetts General Hospital (US)
- Center for Systems Biology (US)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-05-04
- DOI
- https://doi.org/10.1186/s13148-025-01881-5
- Citations
- 3
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- FSHD Global Research Foundation
- Ministero dell’Istruzione, dell’Università e della Ricerca
- National Institutes of Health