CIRBP mRNA level in breast cancer is associated with HIF1α gene expression and microvascular density
The results revealed a significant upregulation of CIRBP (5.07-fold) and HIF1α (4.5-fold) gene expression in BC samples compared to the surrounding normal tissues (p < 0.001). This upregulation was also associated with various clinicopathologic features. Furthermore, there was a correlation between CIRBP mRNA expression, HIF1α mRNA expression, and MVD. Consequently, this study suggests that CIRBP may have a role in promoting angiogenesis in BC.
Authors
- Saeed Ghanbari (ORCID: https://orcid.org/0000-0002-8696-8447)
- Maryam Adelipour (ORCID: https://orcid.org/0000-0002-5670-3595)
- Sajad Monjezi
- Maryam Cheraghzadeh (ORCID: https://orcid.org/0000-0002-5271-0181)
- Vahid Soleimani (ORCID: https://orcid.org/0000-0003-2926-7502)
Institutions
- Ahvaz Jundishapur University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- BMC Research Notes
- Published
- 2025-05-04
- DOI
- https://doi.org/10.1186/s13104-025-07265-5
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Ahvaz Jundishapur University of Medical Sciences