Molecular and immune landscape of melanoma: a risk stratification model for precision oncology

This study provides a robust immune-related prognostic model for melanoma. It underscores the value of immune gene expression and T cell infiltration, particularly CD8+ T cells, in predicting patient outcomes. The model facilitates personalized treatment decisions and advances precision oncology approaches in melanoma. The integration of transcriptomic analysis with experimental validation confirms the tumor-promoting role of KIR2DL4 and enhances the translational value of the model in guiding precision immunotherapy.