Correlates of Processing Speed Change With Combined Cognitive Rehabilitation and Exercise in Progressive MS: Secondary Analysis of the CogEx Trial

BackgroundCognitive rehabilitation and exercise training are promising approaches for improving cognition in persons with progressive multiple sclerosis (MS). Identifying heterogeneity of change and factors that influence the effects of cognitive rehabilitation and/or exercise training on cognitive outcomes at the individual level have direct relevance for developing tailored and optimized rehabilitation interventions for improving cognition in progressive MS.ObjectiveThis study involved a secondary data analysis from the CogEx trial in progressive MS. This study first described heterogeneity of change in cognitive processing speed (CPS) across the intervention conditions and then identified possible adherence/compliance, baseline performance, and demographic/clinical variables as correlates of rehabilitation-related CPS changes.MethodsA total of 311 persons with progressive MS who were pre-screened for impaired CPS completed 12 weeks of combined cognitive rehabilitation (or sham) and exercise training (or sham). CPS was measured before and after the 12-week period. As potential correlates of CPS changes, we measured adherence/compliance (ie, treatment exposure), performance outcomes at baseline, as well as demographic and clinical characteristics at baseline.ResultsThere was heterogeneity of change in CPS across the 4 intervention conditions. We further identified baseline learning and memory impairment and premorbid intelligence quotient (IQ), but not adherence/compliance, other baseline performance outcomes, or demographic/clinical characteristics as significant correlates of CPS changes across the 4 intervention conditions.ConclusionsThe overall pattern of results suggests that future trials in this area might account for impaired learning and memory and/or premorbid IQ as potential covariates, or more carefully consider the role of reserve within rehabilitation interventions in progressive MS.

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Publication Details

Journal
Neurorehabilitation and neural repair
Published
2025-05-04
DOI
https://doi.org/10.1177/15459683251331586
Citations
1
Primary Topic
Multiple Sclerosis Research Studies
Type
article
Field-Weighted Citation Impact
1.47

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article

Correlates of Processing Speed Change With Combined Cognitive Rehabilitation and Exercise in Progressive MS: Secondary Analysis of the CogEx Trial

Massimo Filippi, Anthony Feinstein, Jeremy Chataway, Giampaolo Brichetto et al.
1 citations
Neurorehabilitation and neural repair
Multiple Sclerosis Research Studies
1.47
article

Correlates of Processing Speed Change With Combined Cognitive Rehabilitation and Exercise in Progressive MS: Secondary Analysis of the CogEx Trial

Massimo Filippi, Anthony Feinstein, Jeremy Chataway, Giampaolo Brichetto, Nancy D. Chiaravalloti, Cecilia Meza, Rachel Farrell, Amber Salter, Robert W. Motl, Gary Cutter, Maria Pia Amato, Peter Feys, John DeLuca, Matilde Inglese, Ulrik Dalgas, Brian M. Sandroff, R. Hernandez, Maria Assunta Rocca, Jennifer A. Freeman
article en
1 citations

Abstract

BackgroundCognitive rehabilitation and exercise training are promising approaches for improving cognition in persons with progressive multiple sclerosis (MS). Identifying heterogeneity of change and factors that influence the effects of cognitive rehabilitation and/or exercise training on cognitive outcomes at the individual level have direct relevance for developing tailored and optimized rehabilitation interventions for improving cognition in progressive MS.ObjectiveThis study involved a secondary data analysis from the CogEx trial in progressive MS. This study first described heterogeneity of change in cognitive processing speed (CPS) across the intervention conditions and then identified possible adherence/compliance, baseline performance, and demographic/clinical variables as correlates of rehabilitation-related CPS changes.MethodsA total of 311 persons with progressive MS who were pre-screened for impaired CPS completed 12 weeks of combined cognitive rehabilitation (or sham) and exercise training (or sham). CPS was measured before and after the 12-week period. As potential correlates of CPS changes, we measured adherence/compliance (ie, treatment exposure), performance outcomes at baseline, as well as demographic and clinical characteristics at baseline.ResultsThere was heterogeneity of change in CPS across the 4 intervention conditions. We further identified baseline learning and memory impairment and premorbid intelligence quotient (IQ), but not adherence/compliance, other baseline performance outcomes, or demographic/clinical characteristics as significant correlates of CPS changes across the 4 intervention conditions.ConclusionsThe overall pattern of results suggests that future trials in this area might account for impaired learning and memory and/or premorbid IQ as potential covariates, or more carefully consider the role of reserve within rehabilitation interventions in progressive MS.

Neurorehabilitation and neural repairVol. 39(7)
Rutgers, The State University of New Jersey (US), Sunnybrook Health Science Centre (CA), Vita-Salute San Raffaele University (IT), Queen Mary University of London (GB), University of Toronto (CA), Aarhus University (DK), Kessler Foundation (US), Health Sciences Centre (CA), University of Alabama at Birmingham (US), National Institute for Health and Care Research (GB), University of Illinois Chicago (US), Associazione Italiana Sclerosi Multipla (IT), Don Carlo Gnocchi Foundation (IT), Ospedale Policlinico San Martino (IT), National Hospital for Neurology and Neurosurgery (GB), University of Florence (IT), University College London (GB), University of Genoa (IT), The University of Texas Southwestern Medical Center (US), Hasselt University (BE), University of Plymouth (GB)
Multiple Sclerosis Society of Canada
Openalex Percentile: Top 20%
Multiple Sclerosis Research Studies
1.47
DOISourceOpenAlex
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