Hypoandrogenic state inhibits erectile function in rats via miR-200a-3p
Significant up-regulation of miR-200a-3p in the penile corpus cavernosum of castrated rats inhibited Dlc1 expression, which activated the RhoA/Rho-kinase signaling pathway in smooth muscle cells and inhibited p-eNOS/eNOS in endothelial cells to suppress erectile function. Inhibiting endogenous miR-200a-3p in the penile corpus cavernosum of castrated rats may improve erectile function.
Authors
- Rui Jiang (ORCID: https://orcid.org/0000-0003-1849-3643)
- Yuan Wang (ORCID: https://orcid.org/0009-0009-4893-3284)
- Jun Jiang (ORCID: https://orcid.org/0000-0003-1292-7236)
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- The Journal of Sexual Medicine
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1093/jsxmed/qdaf081
- Primary Topic
- Sexual function and dysfunction studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00