Transcriptomic and lipidomic analysis of aging-associated inflammatory signature in mouse liver
The findings of this study offer new insights into the molecular mechanisms through which the gut microbiota regulates aging-related phenotypes such as inflammation in the liver, possibly through modulating lipid metabolism in a sex-dependent manner.
Authors
- Tomoaki Ishihara (ORCID: https://orcid.org/0009-0005-0037-7443)
- Aki Minoda (ORCID: https://orcid.org/0000-0002-2927-5791)
- Hiroshi Tsugawa (ORCID: https://orcid.org/0000-0002-2015-3958)
- Jen-Chien Chang (ORCID: https://orcid.org/0000-0002-6986-8479)
- Makoto Arita (ORCID: https://orcid.org/0000-0001-9902-0463)
- Seigo Iwanami
Institutions
- Radboud University Nijmegen (NL)
- Keio University (JP)
- Yokohama City University Medical Center (JP)
- Radboud University Medical Center (NL)
- RIKEN Center for Sustainable Resource Science (JP)
- Radboud Institute for Molecular Life Sciences (NL)
- RIKEN Center for Integrative Medical Sciences (JP)
- Yokohama City University (JP)
- Tokyo University of Agriculture and Technology (JP)
Publication Details
- Journal
- Inflammation and Regeneration
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1186/s41232-025-00377-2
- Citations
- 1
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Suzuken Memorial Foundation
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science
- RIKEN
- National Bioscience Database Center
- Exploratory Research for Advanced Technology
- Moonshot Research and Development Program
- Fusion Oriented REsearch for disruptive Science and Technology