Targeting capacity, safety and efficacy of engineered extracellular vesicles delivered by transdermal microneedles to treat plasmacytoma in mice
Enhanced tumor targeting: CD38-modified EVs (CD38-EVs) showed increased uptake by CD38high tumor cells while reducing uptake by CD38-negative non-tumor cells. Optimized delivery: MN-loaded CD38-EVs targeted tumors more effectively than MN-loaded EVs and intravenously injected CD38-EVs, with lower lung and spleen accumulation. Superior antitumor efficacy: MN-delivered CD38-EVs-Dox significantly suppressed tumor growth, outperforming intravenous CD38-EVs-Dox and MN-delivered EVs-Dox.
Authors
- Jiao Qu (ORCID: https://orcid.org/0000-0002-2089-9055)
- Wenlan Chen (ORCID: https://orcid.org/0000-0003-1521-5365)
- B. S. Yang (ORCID: https://orcid.org/0009-0008-5942-316X)
- Yaoying Long (ORCID: https://orcid.org/0000-0003-4517-1375)
- Xuan Hu (ORCID: https://orcid.org/0000-0003-1117-704X)
- Liuyue Xu
- Qiubai Li (ORCID: https://orcid.org/0000-0001-7884-0745)
- Lei Chen (ORCID: https://orcid.org/0000-0003-0018-9993)
- Shan Wang (ORCID: https://orcid.org/0000-0003-3314-6455)
- Hongxiang Wang (ORCID: https://orcid.org/0000-0003-4839-3985)
- Zhichao Chen (ORCID: https://orcid.org/0000-0002-9884-0002)
- Yong Deng (ORCID: https://orcid.org/0000-0002-6936-2523)
- Yulin Cao (ORCID: https://orcid.org/0000-0002-2933-7796)
- Di Wu (ORCID: https://orcid.org/0000-0003-0749-0957)
- Yuxuan Jiang (ORCID: https://orcid.org/0009-0002-6957-4865)
- Yali Yu
- Blal Chakhabi
Institutions
- Union Hospital (HK)
- Hubei University of Science and Technology (CN)
- Wuhan National Laboratory for Optoelectronics (CN)
- Central Hospital of Wuhan (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/ctm2.70327
- Citations
- 6
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China