Co/Ampyrone‐MOF as a Green Nanocatalyst for One‐Pot Synthesis of Xanthene Derivatives

ABSTRACT In the present work, Co/Ampyrone‐MOF was synthesized via the solvothermal method. The synthesized Co/Ampyrone‐MOF was then analyzed using various methods, including SEM, EDX, XRD, and FT‐IR. This metal–organic framework (MOF) was employed as a heterogeneous nanocatalyst in the preparation of xanthene derivatives (3a‐3j) through a one‐pot, solvent‐free condensation reaction. The reaction involved combining two moles of dimedone (2) with one mole of aldehydes (1) at temperatures between 60°C and 70°C. This simple and efficient method resulted in a high yield of xanthene derivatives, short reaction times, and an easy purification process with no unwanted by‐products. Prepared compounds (3a‐3j) underwent PASS online analysis, which revealed that the compounds have displayed inhibitory activity against testosterone 17beta‐dehydrogenase, so a molecular docking study was performed for compounds (3a‐3j) with 1JTV target. The docking results showed a good affinity of the prepared xanthene derivatives to bind with 1JTV protein in comparison with steroidal compound STX1040.