The use of blastocysts developing from nonpronuclear and monopronuclear zygotes can be considered in PGT-SR: a retrospective cohort study
Chromosome abnormalities did not increase the occurrence of abnormal fertilization. There were already a large number of embryos in the PGT-SR population, and routine inclusion of 0PN and 1PN embryos in the PGT-SR cycle is not recommended in this study. Priority should be given to the transfer of 2PN embryos. If a couple receives fewer than three 2PN embryos, or no 2PN embryos at all, it may be considered to include 0PN and 1PN embryos, with preference given to the use of 0PN. Furthermore, genome-wide ploidy and haplotyping are recommended for detection, and aneuploid and ploidy abnormalities are excluded.
Authors
- Shin-Ming Huang (ORCID: https://orcid.org/0000-0003-4273-9682)
- Hongqiang Xie (ORCID: https://orcid.org/0000-0003-2319-5261)
- Jingzhen Wang (ORCID: https://orcid.org/0009-0007-8502-2071)
- Xiaowei Liu (ORCID: https://orcid.org/0009-0000-5475-261X)
- Junhao Yan (ORCID: https://orcid.org/0000-0003-1780-2934)
- Yang Zou (ORCID: https://orcid.org/0000-0002-7335-8850)
- Yuan Gao (ORCID: https://orcid.org/0000-0001-9254-8863)
- Ming Gao (ORCID: https://orcid.org/0000-0003-3695-0713)
- Lijuan Wang (ORCID: https://orcid.org/0000-0001-5944-3453)
Institutions
- Shandong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shandong Academy of Chinese Medicine (CN)
Publication Details
- Journal
- BMC Pregnancy and Childbirth
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1186/s12884-025-07621-0
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Guangxi Key Research and Development Program