Increased Expression of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Brain of Chronic Diabetic Rats
Unlike other synaptic markers (e.g., SNAP25, SYN-1), SV2A levels rise independently of synaptic density, correlating with elevated glutamate and metabolic activity. These findings raise doubt about SV2A's role as a pure synaptic density marker.
Authors
- Burcu Azak Pazarlar (ORCID: https://orcid.org/0000-0003-4199-1974)
- Cansu Bilister Eğilmez (ORCID: https://orcid.org/0000-0003-3644-1433)
- Eser Öz Oyar (ORCID: https://orcid.org/0000-0003-1805-4149)
- Jens D. Mikkelsen (ORCID: https://orcid.org/0000-0001-9824-7359)
Institutions
- University of Copenhagen (DK)
- Izmir Kâtip Çelebi University (TR)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
Publication Details
- Journal
- Synapse
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/syn.70018
- Citations
- 1
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Novo Nordisk
- Novo Nordisk Fonden
- UCB Pharma