THE COMPLEXITY OF BLOOD GLUCOSE REGULATION AND AYURVEDIC INSIGHT

Ayurveda takes a comprehensive approach to blood glucose regulation .Agni, is essential to this; food is converted into energy and tissues depends on strength of agni. When agni is disturbed, Ama (metabolic waste) builds up and affects dhatus, especially meda dhatu (adipose tissue).[i] In addition, Ayurveda views ojas , manas, and atma as essential to metabolic and physiological health. The intricate and precisely regulated physiological mechanism of blood glucose regulation is essential for preserving metabolic health and energy balance. According to contemporary physiology, this regulation entails the coordinated actions of several organs, including the brain, skeletal muscle, liver, adipose tissue, and pancreas, and is controlled by important hormones like glucagon and insulin.[ii] The systemic aspect of glucose homeostasis is highlighted by the responses of other regulators, including cortisol, catecholamines, and incretins, to variables including stress, circadian rhythms, and dietary intake.[iii] The multifaceted intricacy of glucose regulation is shown by the combination of contemporary and Ayurvedic paradigms, providing further insights into systemic health that go beyond molecular mechanisms. [i] Agrawal AK, Yadav CR, Meena MS. Physiological aspects of Agni. Ayu. 2010 Jul;31(3):395-8. doi: 10.4103/0974-8520.77159. PMID: 22131747; PMCID: PMC3221079. [ii] Rix I, Nexøe-Larsen C, Bergmann NC, et al. Glucagon Physiology. [Updated 2019 Jul 16]. In: Feingold KR, Ahmed SF, Anawalt B, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000- Available from: https://www.ncbi.nlm.nih.gov/books/NBK279127/ [iii] Janssen, J.A.M.J.L. New Insights into the Role of Insulin and Hypothalamic-Pituitary-Adrenal (HPA) Axis in the Metabolic Syndrome. Int. J. Mol. Sci. 2022, 23, 8178. https://doi.org/10.3390/ijms23158178