YY1 induced USP13 transcriptional activation drives the malignant progression of hepatocellular carcinoma by deubiquitinating WWP1
Our findings revealed the functional YY1/USP13/WWP1 signaling axis in HCC, identifying a promising therapeutic target for anti-HCC treatment.
Authors
- Di Cui (ORCID: https://orcid.org/0000-0003-2874-6480)
- Qiuran Xu (ORCID: https://orcid.org/0000-0003-2171-9279)
- Qingsong Wu (ORCID: https://orcid.org/0000-0003-2738-5388)
- Qiliang Lu (ORCID: https://orcid.org/0000-0001-8252-2563)
- Xiaoge Hu (ORCID: https://orcid.org/0000-0003-0167-2362)
- Ying Lu (ORCID: https://orcid.org/0000-0003-2204-9983)
- Kangsheng Tu (ORCID: https://orcid.org/0000-0002-0032-1459)
- Wenzhong Shang
- Qiang Huo (ORCID: https://orcid.org/0000-0001-9581-504X)
- Dong‐Sheng Huang (ORCID: https://orcid.org/0000-0003-0080-9128)
- Shuangshuang Li (ORCID: https://orcid.org/0000-0002-5885-3706)
- Zibo Yuan
- Qingwei Zhu
- Lei Zhong (ORCID: https://orcid.org/0000-0002-2974-6231)
- Xin Liu (ORCID: https://orcid.org/0000-0002-0480-5928)
- Junwei Guo (ORCID: https://orcid.org/0000-0002-2203-0070)
- Wen Fu
Institutions
- Qingdao University (CN)
- Zhejiang Chinese Medical University (CN)
- Shandong Provincial Hospital (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Zhejiang Provincial People's Hospital (CN)
- Hangzhou Medical College (CN)
- Anyang Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1186/s11658-025-00733-7
- Citations
- 9
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- Medical Science and Technology Project of Zhejiang Province
- Natural Science Foundation of Zhejiang Province