Visible-Light Induced Etherification of C(sp<sup>3</sup>)–H Bonds with Phenols
The visible-light induced cross-dehydrogenative coupling of C(sp<sup>3</sup>)-H bonds with phenols using BrCCl<sub>3</sub> to give aryl alkyl ethers has been achieved under transition-metal- and photocatalyst-free conditions. This operationally simple and mild protocol has a broad substrate scope, and was applied to the modification of drug molecules and on a gram-scale synthesis. The phenolate ion functions as both a substrate and photosensitizer, and BrCCl<sub>3</sub> serves as the oxidant and hydrogen atom transfer (HAT) agent.
Authors
- Hong‐Xi Li (ORCID: https://orcid.org/0000-0001-8299-3533)
- Zelin Zhao
- David J. Young (ORCID: https://orcid.org/0000-0001-9947-6655)
- Xinhua Lu (ORCID: https://orcid.org/0000-0001-8132-8697)
- Zhi‐Gang Ren (ORCID: https://orcid.org/0000-0002-0740-8397)
- Xin Fang (ORCID: https://orcid.org/0000-0003-2990-2617)
- Jing Qian (ORCID: https://orcid.org/0000-0001-9523-2282)
Institutions
- University of Glasgow (GB)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1021/acs.orglett.5c01018
- Citations
- 2
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Priority Academic Program Development of Jiangsu Higher Education Institutions