Calpain1 inhibition enhances autophagy-lysosomal pathway and ameliorates tubulointerstitial fibrosis in Nephronophthisis
Calpain1-mediated autophagy-lysosomal pathway disorder may be an important cause of tubulointerstitial fibrosis in NPH. Calpain1 may have therapeutic implications for renal tubulointerstitial fibrosis.
Authors
- Huamu Chen
- Xinyu Su (ORCID: https://orcid.org/0000-0003-1890-8810)
- Jiayong Lai (ORCID: https://orcid.org/0000-0002-3214-1233)
- Liangzhong Sun (ORCID: https://orcid.org/0000-0003-1962-8626)
- Jinglan Zhang (ORCID: https://orcid.org/0000-0002-4600-7123)
- Haiyan Wang (ORCID: https://orcid.org/0000-0003-4206-0215)
- Yaqing Liu (ORCID: https://orcid.org/0000-0002-2885-1670)
- Yanlin Yang (ORCID: https://orcid.org/0000-0003-4979-1248)
- Xiaoya Wei
- Dantong Li (ORCID: https://orcid.org/0009-0009-4054-7311)
Institutions
- Nanfang Hospital (CN)
- First Affiliated Hospital of Gannan Medical University (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1186/s10020-025-01231-4
- Citations
- 2
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.63
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Guangdong Medical Research Foundation
- Guangzhou Municipal Science and Technology Project