Impact of mutations in immunodominant regions of SARS-CoV-2 variants on recognition by CD8+ T cell: An in silico analysis
Brazilian HLA-I-restricted CD8+ T cell epitopes from SARS-CoV-2 immunodominant regions are partially conserved in the Gamma, Delta, and Omicron variants circulating in Brazil, suggesting effective a cross-protective immune response that may help reduce COVID-19 severity and mortality.
Authors
- Filipe Ferreira de Almeida Rego (ORCID: https://orcid.org/0000-0002-6102-6672)
- Carlos Gustavo Regis da Silva
- Greice Carolina Santos da Silva (ORCID: https://orcid.org/0000-0002-6066-6344)
- Victoria Cruz Paraná
- Marcos Roberto Gomes de Queiroz (ORCID: https://orcid.org/0000-0002-7890-3248)
- Maria Fernanda Rios Grassi (ORCID: https://orcid.org/0000-0002-7356-5569)
- Manuel Portela
- Raimundo Coutinho
- Luana Leandro Gois
Institutions
- Universidade Federal da Bahia (BR)
- Escola Bahiana de Medicina e Saúde Pública (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Journal of Infection and Public Health
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1016/j.jiph.2025.102803
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado da Bahia
- Fundação Nacional de Desenvolvimento do Ensino Superior Particular