PEBL, a component-based Chinese medicine, reduces virus-induced acute lung injury by targeting FXR to decrease ACE2 levels
This study provides the first evidence that PEBL offers protective effects against ALI induced by acute respiratory viruses. PEBL prevents FXR from binding to ACE2 by inhibiting FXR transcription, which reduces macrophage infiltration, cytokine storm formation, and inflammatory injury, thereby ameliorating viral ALI. These findings underscore the potential of PEBL as a candidate for further exploration in the treatment of viral ALI.
Authors
- Jiayang He (ORCID: https://orcid.org/0000-0002-2082-4686)
- Hongyan Ding
- Weifu Tan (ORCID: https://orcid.org/0000-0002-6192-3920)
- Xiangjun Zhou (ORCID: https://orcid.org/0000-0001-7480-507X)
- Qinhai Ma
- Wei Li (ORCID: https://orcid.org/0000-0002-4264-1864)
- Jingtao Yu (ORCID: https://orcid.org/0009-0001-1916-0384)
- Huihui Cao
- Guangli Yang (ORCID: https://orcid.org/0000-0002-5097-5266)
- Junshan Liu (ORCID: https://orcid.org/0000-0002-9326-6312)
- Xiaochuan Fang
- Liling Yang (ORCID: https://orcid.org/0009-0009-9300-3801)
- Zibin Lu (ORCID: https://orcid.org/0000-0001-7174-9420)
- Linzhong Yu
Institutions
- Guangdong Medical College (CN)
- Guangdong Pharmaceutical University (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Dongguan University of Technology (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Dongguan People’s Hospital (CN)
- TCM-Intigrated Cancer Center of Southern Medical University (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1016/j.jare.2025.05.003
- Citations
- 2
- Primary Topic
- Vitamin C and Antioxidants Research
- Type
- article
- Field-Weighted Citation Impact
- 2.24