NRXN3 regulates pyroptosis in intrahepatic cholangiocarcinoma via mediating the phospho-dependent ubiquitination and degradation of caspase-3
NRXN3 plays a crucial role in maintaining chemotherapy-induced pyroptosis in ICC. Targeting the NRXN3/RSK1/FBXO1/caspase-3 axis emerges as a promising strategy for ICC treatment, with the potential to improve chemosensitivity and survival.
Authors
- Jifei Wang (ORCID: https://orcid.org/0000-0002-4724-3080)
- Yirui Wang (ORCID: https://orcid.org/0000-0001-5767-3343)
- Xiangcheng Li (ORCID: https://orcid.org/0000-0002-8878-7332)
- Jiang Chang (ORCID: https://orcid.org/0000-0002-8300-8723)
- Yaodong Zhang (ORCID: https://orcid.org/0000-0003-0014-025X)
- Tao Zhou (ORCID: https://orcid.org/0000-0003-2219-6385)
- Tianlin Wang
- Changxian Li (ORCID: https://orcid.org/0000-0002-2291-604X)
- Yananlan Chen
- Ruixiang Chen (ORCID: https://orcid.org/0009-0004-4861-9758)
- Shenye Shao
- Wangjie Jiang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Wuxi People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1016/j.jare.2025.04.040
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81