Nanoconfinement of Ammonia Borane via Hybrid‐Phased Titanate Nanocrystals Enables Sustained H<sub>2</sub> Release for Diabetic Bone Repair
Despite its potential in hydrogen (H<sub>2</sub>) therapy, ammonia borane (AB) has limited biomedical applications due to its uncontrolled hydrolysis rate and potential to cause cytotoxicity. Existing material-based delivery strategies focus on accelerating AB hydrolysis for H<sub>2</sub> production, hence exacerbating these issues. A new nanoconfinement strategy is reported, which loads AB onto oxygen-deficient, hybrid-phased titanate nanocrystals on implant surfaces through a unique one-end-anchored docking (OEAD) mechanism. This nanoconfinement strategy effectively restricts the release of AB molecules, allowing only water molecules to infiltrate the interlayer space for slow hydrolysis and sustained H<sub>2</sub> release. This significantly prolongs the duration of H<sub>2</sub> release and effectively circumvents the cytotoxicity associated with AB interacting with hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) in the inflammatory microenvironment. In vitro and in vivo have shown that sustained H<sub>2</sub> release from the implant surface effectively alleviates diabetes-related oxidative stress, and combined with the release of magnesium ions (Mg<sup>2+</sup>) synergistically promotes innervated-vascularized bone regeneration.
Authors
- Minggang Yang (ORCID: https://orcid.org/0000-0001-8115-3495)
- Haibo Tao
- Qingqing Guan
- Benjamin M. Wu (ORCID: https://orcid.org/0000-0001-5236-8534)
- Jiao Jiao Li (ORCID: https://orcid.org/0000-0002-3584-6765)
- Pei Jia
- Zundong Liu
- Sergio Moya (ORCID: https://orcid.org/0000-0002-7174-1960)
- Fuwei Liu (ORCID: https://orcid.org/0000-0001-8942-6697)
- Zhengjiang Xu
- Yuan Zhang (ORCID: https://orcid.org/0000-0003-0670-2428)
- Yi‐Chen Chen (ORCID: https://orcid.org/0000-0002-4616-2115)
- Xin He (ORCID: https://orcid.org/0000-0002-7999-5981)
- Guocheng Wang (ORCID: https://orcid.org/0000-0002-8235-4472)
- Liang Kong (ORCID: https://orcid.org/0000-0003-4960-1993)
- Xiaobing Zhao (ORCID: https://orcid.org/0000-0003-1217-8650)
- Junkang Chen (ORCID: https://orcid.org/0009-0009-3939-0708)
- Haobo Pan (ORCID: https://orcid.org/0000-0002-8775-8572)
Institutions
- University of Technology Sydney (AU)
- Fujian Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Sciences (CN)
- Yanshan University (CN)
- CIC biomaGUNE (ES)
- Second Affiliated Hospital of Fujian Medical University (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Changzhou University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Advanced Materials
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1002/adma.202502741
- Citations
- 4
- Primary Topic
- Hydrogen's biological and therapeutic effects
- Type
- article
- Field-Weighted Citation Impact
- 8.03
Funders
- National Natural Science Foundation of China
- Development and Reform Commission of Shenzhen Municipality