Myocardial infarction and pulmonary embolism in a young man during feminizing gender-affirming therapy: а case report

More than 100 million women use combined oral contraceptives to prevent unintended pregnancy, as well as for a number of other medical indications. Taking estrogen and progestin drugs is associated with the risk of acute thromboembolic and vascular events. This is a consequence of an increase in serum coagulation factors and a direct effect on endothelial dysfunction, which enhances platelet aggregation. This article demonstrates the development of myocardial infarction and pulmonary embolism in a young man during feminizing therapy.