Omeprazole exacerbates intervertebral disc degeneration through Caspase-3 mediated apoptosis of nucleus pulposus cells: a Mendelian randomization, network toxicology, and in vitro experimental study
This study found that taking omeprazole may exacerbate IVDD, and its potential mechanism is through CASP3 leading to apoptosis of NPCs. These findings advocate cautious long-term omeprazole use in clinical practice and suggest alternative PPIs.
Authors
- Hai-Fan Zhao (ORCID: https://orcid.org/0000-0001-8926-7729)
- Baoshan Xu
- Shengbo Huang (ORCID: https://orcid.org/0009-0006-2231-1418)
- Yuchao Jia
Institutions
- Tianjin Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1186/s13018-025-05863-4
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tianjin Municipal Health Commission