Highly sensitive and specific markers for detection of mismatch repair deficiency by next-generation sequencing
We propose that this approach allows one to identify highly sensitive and specific markers for detecting dMMR CRC by NGS alone. Further studies are warranted to test whether these markers are applicable to non-CRC neoplasms.
Authors
- Aparna Pallavajjala
- Eric S. Christenson (ORCID: https://orcid.org/0000-0001-5261-6083)
- Ming-Tseh Lin
- James R. Eshleman (ORCID: https://orcid.org/0000-0002-9274-8459)
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Johns Hopkins Hospital (US)
Publication Details
- Journal
- American Journal of Clinical Pathology
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1093/ajcp/aqaf026
- Citations
- 1
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.47