SMAD2 linker phosphorylation impacts overall survival, proliferation, TGFβ1-dependent gene expression and pluripotency-related proteins in NSCLC
pSMAD2L antagonises anti-proliferative canonical TGFβ-signalling in NSCLC and redirects TGFβ1-dependent gene expression, whereas loss of pSMAD2L enhances SMAD2<sup>ΔE3</sup> and affects pluripotency-associated proteins in vitro. In NSCLC patients, pSMAD2L cell density influences disease-free and overall survival in a spatially distinct manner.
Authors
- Daniel Drömann (ORCID: https://orcid.org/0000-0002-5878-8887)
- Ole Ammerpohl (ORCID: https://orcid.org/0000-0003-3539-2326)
- Klaus F. Rabe (ORCID: https://orcid.org/0000-0002-7020-1401)
- Dörte Nitschkowski (ORCID: https://orcid.org/0000-0002-5347-6403)
- Norbert Reiling (ORCID: https://orcid.org/0000-0001-6673-4291)
- Georgios T. Stathopoulos (ORCID: https://orcid.org/0000-0002-9215-6461)
- Holger Heine
- Kristina A. M. Arendt (ORCID: https://orcid.org/0000-0002-4427-9379)
- Martin Reck (ORCID: https://orcid.org/0000-0002-5336-9739)
- Sebastian Marwitz (ORCID: https://orcid.org/0000-0003-4920-5552)
- Jochen Behrends (ORCID: https://orcid.org/0000-0002-0648-8911)
- Mark Kriegsmann (ORCID: https://orcid.org/0000-0002-7319-3646)
- Thomas Muley (ORCID: https://orcid.org/0000-0002-8141-0604)
- Tim Vierbuchen (ORCID: https://orcid.org/0000-0003-3110-4155)
- Torsten Goldmann (ORCID: https://orcid.org/0000-0002-1621-560X)
- Christian Kügler
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Helmholtz Zentrum München (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- University Hospital Schleswig-Holstein (DE)
- Research Center Borstel - Leibniz Lung Center (DE)
- German Center for Lung Research (DE)
- LungenClinic Grosshansdorf (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1038/s41416-025-02970-1
- Citations
- 2
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Deutsches Zentrum für Lungenforschung
- Leibniz-Gemeinschaft