Biochemical parameters and quality of life response to life style modification in obese with type 2 diabetes mellitus

Globally, type 2 diabetes mellitus (T2DM) is an epidemic medical problem that adversely affect the patient’s functional capacity and quality of life (QoL). This study designed to examine the effects of weight reduction program on biochemical parameters and quality of life for obese T2DM patients. Eighty obese subjects with T2DM (48 males and 32 females), the range of their body mass index (BMI) was 30 to 34 Kg/m2. Smoking, pregnancy, heart, kidney, hepatic and respiratory failure were the main exclusion criteria. Participants randomly assigned into two study groups; group (A) enrolled in weight-reducing program composed of aerobic exercise and diet regimen. However, group (B) received no clinical intervention. All participants signed the informed consent. Weight reducing program of group (A) resulted in significant increase in mean values of SF-36 subscale scores, HDL cholesterol and QUICKI. In addition to significant increase in mean values of LDL cholesterol, TC, TG, HOMA-IR and BMI. Changes of group (B) were not significant. Moreover, comparison between both groups revealed significant differences at the end of the study. Weight reducing program improves quality of life and selected biochemical parameters of obese type 2 diabetics.