The biomarker potential of circPOLD1 and its binding protein YBX1 in cervical carcinogenesis
circPOLD1 and YBX1 synergistically drive cervical carcinogenesis and exhibit stage-specific expression patterns. Their combined detection significantly enhanced the accuracy for cervical cancer screening and dynamic monitoring. The successful application of BaseScope and IHC highlights the immediate translational potential of these biomarkers, paving the way for refined risk stratification, improved therapeutic targeting, and reduced cervical cancer burden through early intervention.
Authors
- Zhao Lu (ORCID: https://orcid.org/0000-0003-1298-8936)
- Tingjia Zhu
- Xiaodong Cheng (ORCID: https://orcid.org/0000-0002-6073-7261)
- Lingfang Wang (ORCID: https://orcid.org/0000-0002-9002-3657)
- Yixuan Cen (ORCID: https://orcid.org/0000-0002-2185-545X)
- Xin Chen (ORCID: https://orcid.org/0000-0003-3024-9053)
- Yanan Zhang (ORCID: https://orcid.org/0000-0001-8289-0788)
- Junfen Xu (ORCID: https://orcid.org/0000-0002-2377-0775)
- Xing Xie (ORCID: https://orcid.org/0000-0002-1636-4816)
- Yang Li (ORCID: https://orcid.org/0000-0002-4308-5118)
- Lili Xia (ORCID: https://orcid.org/0000-0003-3924-7513)
- Weiguo Lü (ORCID: https://orcid.org/0000-0003-2062-7145)
Institutions
- Peking University (CN)
- Peking University People's Hospital (CN)
- Women's Hospital, School of Medicine, Zhejiang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-03
- DOI
- https://doi.org/10.1186/s12967-025-06494-3
- Citations
- 2
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Zhejiang University